With the rise of weight loss medications like Ozempic, any time a celebrity debuts a dramatic weight loss, it’s hard for them to beat the GLP-1 allegations. Once upon a time, these drugs were mostly used to treat Type 2 diabetes, but in recent years, they’ve become a go-to for instant weight loss in Hollywood. Oprah called them “tools” for keeping people healthy, but many celebs have outright denied using them. Here are 10 stars who are the subject of Ozempic rumors.
Adele
Adele has churned out plenty of smash hits and has done so while fighting the unrealistic body-image standards that pop stars continue to face. In 2012, she said, “I don’t want to be some Skinny Minnie with my t*** out.” However, in 2020, she went viral for showcasing a 100-pound weight loss. Although she claimed that her weight loss was achieved through diet and workouts, many speculated it was actually due to semaglutide, particularly because of her hollowed cheeks.
Jonah HIll
While Jonah Hill’s earlier roles were mostly informed by his regular Joe appearance and being overweight, he gave himself a makeover when he shed a ton of weight. In his 2026 movie “Outcome,” he’s looking slimmer than ever, with one nutritionist telling Hello! Magazine that he dropped around 200 pounds. He’s faced accusations of Ozempic face more than once.
Kim and Khloe Kardashian
While she started out naturally curvy, Kim K has lost a decent amount of weight over the years. In 2022, she admitted that she achieved double-digit weight loss in just weeks to fit into a dress that Marilyn Monroe once wore. One Redditor said, “The Ozempic era definitely started with Marilyn’s dress,” and her name was connected with the drug over the years. Khloe also underwent a significant transformation, and although she hasn’t explicitly stated it, she expressed her willingness to try it when she was younger.
50 Cent
Rapper 50 Cent is known for having a bulky body type, but he lost 43 pounds in 2024, and many said it was thanks to a GLP-1. 50 Cent’s response? “Everybody talking about weight loss. I was in the gym. I was working the f*** out, man. Who says Ozempic? I was running. I was running, I was doing what I had to do. … I was 253 pounds, I came down and I’m 210 right now. Oww, so how you feel about it?”
